Clindamycin Phosphate
Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic clindamycin. It is used systemically via intravenous or intramuscular injection, topically for dermatological conditions like acne, or intravaginally. It works by binding to the 50S ribosomal subunit of susceptible bacteria, thereby preventing peptide bond formation and inhibiting bacterial protein synthesis.
Dosage by Body Weight
Dosage varies significantly based on the route of administration (topical, vaginal, or intravenous/intramuscular) and the severity of the infection. Systemic pediatric dosing is typically calculated by body weight at 20 to 40 mg/kg/day in 3 to 4 divided doses. Always follow a healthcare provider's precise instructions.
- Body Weight
- Below 5 kg
- Dose
- Not routine / Individualized weight-based calculation required (typically 15 to 20 mg/kg/day)
- Frequency
- Divided into 3 to 4 doses daily
- Tracking Notes
- Use only under strict specialist pediatric supervision. Safe use in neonates under 1 month has not been fully established for all routes.
- Body Weight
- 5-7 kg
- Dose
- 100 mg to 280 mg total daily dose
- Frequency
- Divided into 3 or 4 equal doses (every 6 to 8 hours)
- Tracking Notes
- Calculated at 20-40 mg/kg/day based on the severity of the infection. Administered via IV or IM injection.
- Body Weight
- 8-10 kg
- Dose
- 160 mg to 400 mg total daily dose
- Frequency
- Divided into 3 or 4 equal doses (every 6 to 8 hours)
- Tracking Notes
- Dose must be determined by a healthcare provider. Close monitoring of liver and renal function is advised.
- Body Weight
- 11-15 kg
- Dose
- 220 mg to 600 mg total daily dose
- Frequency
- Divided into 3 or 4 equal doses (every 6 to 8 hours)
- Tracking Notes
- For severe infections, higher end of the range is preferred under clinical supervision.
- Body Weight
- 16-20 kg
- Dose
- 320 mg to 800 mg total daily dose
- Frequency
- Divided into 3 or 4 equal doses (every 6 to 8 hours)
- Tracking Notes
- Do not exceed maximum pediatric daily limits unless specifically directed by an infectious disease specialist.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / Individualized weight-based calculation required (typically 15 to 20 mg/kg/day) | Divided into 3 to 4 doses daily | Use only under strict specialist pediatric supervision. Safe use in neonates under 1 month has not been fully established for all routes. |
| 5-7 kg | 100 mg to 280 mg total daily dose | Divided into 3 or 4 equal doses (every 6 to 8 hours) | Calculated at 20-40 mg/kg/day based on the severity of the infection. Administered via IV or IM injection. |
| 8-10 kg | 160 mg to 400 mg total daily dose | Divided into 3 or 4 equal doses (every 6 to 8 hours) | Dose must be determined by a healthcare provider. Close monitoring of liver and renal function is advised. |
| 11-15 kg | 220 mg to 600 mg total daily dose | Divided into 3 or 4 equal doses (every 6 to 8 hours) | For severe infections, higher end of the range is preferred under clinical supervision. |
| 16-20 kg | 320 mg to 800 mg total daily dose | Divided into 3 or 4 equal doses (every 6 to 8 hours) | Do not exceed maximum pediatric daily limits unless specifically directed by an infectious disease specialist. |
Formulation
Purpose
Used to treat severe bacterial infections (including respiratory tract, skin and soft tissue, intra-abdominal, and gynecological infections), acne vulgaris (topically), and bacterial vaginosis (vaginally).
Generic Name
Clindamycin PhosphateBranded Drug Names
Clindamycin Phosphate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.